SYNERGIC-2 Trial (SYNchronizing, Exercises and Remedies to GaIn Cognition@home)

What is this Study about?

SYNERGIC-2 is a 12-month home-based personalized multidomain lifestyle intervention to improve cognition in older adults with Mild Cognitive Impairment (MCI), a pre-dementia state. These personalized at-home interventions target 5 domains with tailored physical exercise, cognitive training, diet recommendations, sleep interventions, and vascular risk factor management and are all delivered using a digital platform. SYNERGIC-2 will be conducted with participants in their homes using video-conference meetings to test participants and to coach them 1-on-1 through the interventions on a web-based digital platform. The effect of these combined interventions on cognition will be compared to an online-educational program Brain Health PRO (BHPro).

What Will Happen in This Study?

If you decide to participate then you will be "randomized" into one of the study groups described below. Randomization means that you are put into a group by chance. It is like flipping a coin. There is no way to predict which group you will be assigned to. Neither you, the study staff, nor the study doctor can choose what group you will be in. You will have a 50/50 chance of being placed in either group. You will be notified which group you are in.

Who is Eligible to Participate in this Study?

- Aged 60-85 years.

- Concerned about memory or thinking problems.

- Have access to internet at home.

- Ability to speak English.

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