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  • Clinical Trial
    Online

    What is this Study about?

    Scientific evidence indicates that healthy lifestyle habits promote brain health and help prevent Alzheimer’s disease.

    Our study consists of evaluating a personalized program designed to promote healthy lifestyle habits with the goal of supporting brain health.

    This program, called Luci, is available as an online platform with virtual guidance from an advisor. Its purpose is to help participants change their lifestyle habits. It focuses on three areas: physical activity, healthy eating, and intellectual stimulation.

    The aim of this study is to determine whether our program helps improve lifestyle habits in these three areas, along with other indicators linked to brain health.

    Eligibility Criteria

    You are eligible to participate if you:

    • Are aged between 50 and 75 years of age

    • Have not been diagnosed with a cognitive disorder, such as Alzheimer’s disease

    • Wish to adopt healthy lifestyle habits in at least one of the following domains: physical activity, healthy eating, and intellectual stimulation

    • Have access to a tablet or computer with an internet connection

    • Are able to speak English or French

    Recruitment End Date

  • Clinical Trial
    Online

    What is this Study about?

    The Communication Bridge 3 Study is focused on helping adults with mild to moderate Primary Progressive Aphasia (PPA), a condition that affects language abilities due to neurodegenerative diseases. The study aims to improve functional communication and life participation by providing structured language and communication support remotely through video conferencing.

    Participants work with speech-language pathologists to practice communication techniques and learn strategies to address daily communication challenges. The study involves a series of therapy sessions, assessments, and follow-up evaluations to measure changes in communication and participation over time. By tracking participants' progress, the study hopes to identify effective approaches for enhancing quality of life for those living with PPA and their care partners.

    Eligibility Criteria

    You are eligible to participate if you speak English as a primary language, a confirmed diagnosis of PPA in mild to moderate impairment stage, a communication partner that is willing to participate, and sufficient internet connection.

    Recruitment End Date

  • Clinical Trial
    In-Person

    What is this Study about?

    The purpose of this study is to assess the effectiveness, safety, and tolerability of BMS-986446 an Anti-MTBR Tau Monoclonal Antibody in participants with Early Alzheimer's Disease.

    Eligibility Criteria

    Male or female participants aged 50 to 80 years of age
    MCI or Mild AD at Screening
    Must have a study partner

    Recruitment End Date

  • Clinical Trial
    In-Person

    What is this Study about?

    This AR1001-ADP3-US01 protocol is a double-blind, randomized, placebo-controlled, multi- center, parallel-group comparison pivotal Phase 3 study to evaluate the efficacy and safety of AR1001 for the treatment of participants with early AD.

    Eligibility Criteria

    Male or female participants aged 55 to 90 years of age
    MCI or Mild AD at Screening
    Must have a study partner

    Recruitment End Date

  • Clinical Trial
    Ontario

    What is this Study about?

    McMaster University, in partnership with Ressam Gardens Memory Care Community, is conducting a study on the effects of brain stimulation in individuals aged 50 and older with dementia or memory loss. The research focuses on using repetitive transcranial magnetic stimulation (rTMS), a non-invasive technique that delivers magnetic pulses to the brain, to enhance cognitive function and balance. The goal is to extend the positive effects of brain stimulation in improving cognition and balance in individuals with dementia.

    Eligibility Criteria

    You are eligible to participate if you…

    1.) Diagnosed with Dementia and/or memory loss by a clinician

    2.) Exhibit adequate oral communication skills and cognitive function sufficient to obtain a score ranging between 10-27 on the Mini-Mental State Exam

    3.) Walk or stand with or without personnel or assistive devices

    4.) Individuals must be greater than or equal to 50 years of age

    Recruitment End Date

  • Clinical Trial
    Online

    What is this Study about?

    The goal of the proposed SYNERGIC-2 TRIAL (SYNchronizing Exercises, and Remedies to GaIn Cognition@home) is to evaluate cognitive improvements from personalized multidomain interventions that target multiple dementia risk factors delivered at home to older adults with Mild Cognitive Impairment (MCI).

    Eligibility Criteria

    - Aged 60-85 years.

    - Concerned about memory or thinking problems.

    - Have access to internet at home.

    - Ability to speak English.

    Recruitment End Date

  • Clinical Trial
    In-Person

    What is this Study about?

    It is expected that the information collected during this study will be used in analyses and will be published/presented to the scientific community at meetings and in journals. This information may also be used as part of a submission to regulatory authorities around the world to support the approval of the study intervention for agitation in AD.

    Eligibility Criteria

    You are eligible to participate if you meet the following criteria:

    • Age ≥ 55; females must be post-menopausal

    • DSM-5 criteria for Major Neurocognitive Disorder due to AD; multiple etiologies (AD and vascular)

    • sMMSE ≤ 24

    • Clinically significant agitation based on IPA definition

    • Stable cognition-enhancing medication for at least 3 months prior to study enrolment

    • Availability of a caregiver to accompany participant to study visits and to participate in the study

    • Ability to speak English

    Recruitment End Date

  • Clinical Trial
    Online & In-Person

    What is this Study about?

    To examine the effects of a stress management program on well-being, stress, and cognition in family caregivers of someone with dementia or a related neurodegenerative disorder. We will be recruiting participants from 2023 - 2027.

    Eligibility Criteria

    - are a primary family caregiver of a person with dementia or a related neurodegenerative disorder.

    - have access to a computer with high-speed internet; and feel comfortable using email and Zoom (a secure online meeting platform).

    - have a video camera on your device. To ensure safety of participants during the program sessions, it is important that participants turn on their video camera. Keeping the video camera on is also important to build trust within the group sessions and when interacting with the researchers.

    - are willing to be randomised to one of 3 groups, even if it is not your preferred group.

    - are able to commit to a synchronous 8-week online group-based program (described below) and complete daily prescribed daily home practices.

    - are able to commit to three assessment sessions: one baseline assessment, one post-program assessment, one 12-month follow-up assessment.

    - agree to audio recording of interview sessions and portions of the assessment that require accurate verbal data collection.

    - are able to provide blood samples, potentially after a 12-hour fast.

    - are able to travel to a LifeLabs clinic for biomarker collection.

    - agree to refrain from participating in new studies or programs during the 8-week study session.

    - meet the screening criteria during the pre-screening interview.

    - ability to speak English.

    Recruitment End Date