Selecting one or more of the options below will update the content below.

Age Group
Type of Study
Study Format
Location
Target Population
  • Observational Study
    Online & In-Person

    Sensory Processing in Aging and Neurodegenerative Disease

    What is this Study about?

    We are interested in how the brain changes in aging and with dementia. With this study, we will investigate how the brain senses and interprets sights and sounds. We are particularly interested in how listening to music, especially familiar music, evokes emotions and activates vivid memories. Learning how the brain processes music will help us understand why music therapy is such an effective tool for those with Alzheimer’s. We also aim to understand how the brain combines sights and sounds. This is an important part of how we navigate complex everyday situations, such as walking down a busy street. Alzheimer’s disease interferes with the brain’s ability to combine information from different senses, which could cause challenges in daily living.

    Eligibility Criteria

    You are eligible to participate in this study if you are:

    • A healthy young adult aged 18-35, a healthy older adult aged 65 and up, or an older adult with mild/early-stage dementia as diagnosed by your doctor
    • Able to provide written, informed consent to participate
    • Have normal or corrected-to-normal hearing in both ears and vision in both eyes
    • You must have no history of cerebro-vascular injury or accident (such as a stroke)
    • For adults without dementia, you must have no known neurological conditions and must not be taking any neuroactive drugs

    You will not be eligible to participate in the study if you:

    • Have metallic objects that cannot be removed for the MEG recording (such as permanent piercings and medical implants that are made from magnetic metals)
    • Are pregnant
    • Feel you cannot perform the audio-visual and/or music listening tasks

    Recruitment End Date

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  • Clinical Trial
    Online

    Communication Bridge 3 (CB3) Clinical Trial

    What is this Study about?

    The Communication Bridge 3 Study is focused on helping adults with mild to moderate Primary Progressive Aphasia (PPA), a condition that affects language abilities due to neurodegenerative diseases. The study aims to improve functional communication and life participation by providing structured language and communication support remotely through video conferencing.

    Participants work with speech-language pathologists to practice communication techniques and learn strategies to address daily communication challenges. The study involves a series of therapy sessions, assessments, and follow-up evaluations to measure changes in communication and participation over time. By tracking participants' progress, the study hopes to identify effective approaches for enhancing quality of life for those living with PPA and their care partners.

    Eligibility Criteria

    You are eligible to participate if you speak English as a primary language, a confirmed diagnosis of PPA in mild to moderate impairment stage, a communication partner that is willing to participate, and sufficient internet connection.

    Recruitment End Date

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  • Clinical Trial
    In-Person

    Study to Evaluate the Efficacy, Safety, and Tolerability of an Anti-MTBR Tau Monoclonal Antibody (BMS-986446) in Participants With Early Alzheimer's Disease (TargetTau-1)

    What is this Study about?

    The purpose of this study is to assess the effectiveness, safety, and tolerability of BMS-986446 an Anti-MTBR Tau Monoclonal Antibody in participants with Early Alzheimer's Disease.

    Eligibility Criteria

    Male or female participants aged 50 to 80 years of age
    MCI or Mild AD at Screening
    Must have a study partner

    Recruitment End Date

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  • Clinical Trial
    In-Person

    Phase 3, Double-blind, Randomized, Placebo-controlled Trial to Evaluate the Efficacy and Safety of AR1001 in Participants with Early Alzheimer's Disease (Polaris-AD)

    What is this Study about?

    This AR1001-ADP3-US01 protocol is a double-blind, randomized, placebo-controlled, multi- center, parallel-group comparison pivotal Phase 3 study to evaluate the efficacy and safety of AR1001 for the treatment of participants with early AD.

    Eligibility Criteria

    Male or female participants aged 55 to 90 years of age
    MCI or Mild AD at Screening
    Must have a study partner

    Recruitment End Date

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  • Observational Study
    Online & In-Person

    Bridge2AI-Voice as a Biomarker of Health

    What is this Study about?

    The aim of this study is to develop a large, ethically sourced, and diverse database of voice recordings to determine whether voice has biomarkers for particular disease categories, including neurological and neurodegenerative conditions. The data that is collected will be used to develop a full open-access database to fuel artificial intelligence research related to voice.

    Eligibility Criteria

    - Are between the ages of 44-85

    - Are able to read, write, speak, and understand English

    - Are diagnosed with one of the following conditions:

    • Alzheimer's disease
    • Parkinson's disease
    • Amyotrophic Lateral Sclerosis
    • Mild Cognitive Impairment, or other types of dementia

    - Consent to provide a voice/speech sample

    Recruitment End Date

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  • Observational Study
    In-Person

    Understanding Task Sequencing in People with Mild Cognitive Impairment (MCI) and Dementia

    What is this Study about?

    This study examines how people with dementia or MCI perform household tasks, focusing on when they seek support, and which prompts help them complete tasks. The findings will help develop technologies to assist them in completing tasks more independently and safely.

    Eligibility Criteria

    You are eligible to participate if you are:

    • An older adult aged 60-85

    • Fluent in English

    • Diagnosed with dementia or MCI

    • Enrolled in outpatient care

    Recruitment End Date

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  • Clinical Trial
    Ontario

    Accelerated intermittent theta burst stimulation to enhance cognitive function and balance in dementia

    What is this Study about?

    McMaster University, in partnership with Ressam Gardens Memory Care Community, is conducting a study on the effects of brain stimulation in individuals aged 50 and older with dementia or memory loss. The research focuses on using repetitive transcranial magnetic stimulation (rTMS), a non-invasive technique that delivers magnetic pulses to the brain, to enhance cognitive function and balance. The goal is to extend the positive effects of brain stimulation in improving cognition and balance in individuals with dementia.

    Eligibility Criteria

    You are eligible to participate if you…

    1.) Diagnosed with Dementia and/or memory loss by a clinician

    2.) Exhibit adequate oral communication skills and cognitive function sufficient to obtain a score ranging between 10-27 on the Mini-Mental State Exam

    3.) Walk or stand with or without personnel or assistive devices

    4.) Individuals must be greater than or equal to 50 years of age

    Recruitment End Date

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  • Observational Study
    In-Person

    Resting-state measures of language experience and cognitive reserve in aging and cognitive impairment

    What is this Study about?

    This study will uncover how bilingualism supports healthy cognitive aging by examining the influence of different language experiences on the timing and location of brain network activity. We will examine the timing of brain activity using electroencephalography (EEG; i.e., recordings of electrical brain activity) and the location of brain activity using magnetic resonance imaging (MRI; i.e., images of activity in different parts of the brain). Different language experience factors will additionally be explored. By measuring multiple factors (e.g., the age of second language learning, language proficiency) the effect(s) of different language experiences on the brain and cognition will become clearer.

    Eligibility Criteria

    You are eligible to participate if you:

    - are a French-English bilingual over the age of 65

    - have mild cognitive impairment

    - have Alzheimer's disease

    - are a healthy older adult (i.e., have no cognitive conditions)

     

    Please note that you do not need to be completely fluent in both English and French, just to have some familiarity, experience or training with both languages to be eligible to participate.

    Thank you for your consideration!

    Recruitment End Date

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  • Observational Study
    Online

    CAN-PROTECT

    What is this Study about?

    CAN-PROTECT is a Canada-wide online study recruiting participants and caregivers of persons with dementia to explore how lifestyle, background, and caretaking factors affect our health, quality of life, cognition, behaviour, and function as we age. CAN-PROTECT data will be analyzed and jointly published by the University of Calgary in partnership with the University of Exeter.

    Eligibility Criteria

    - Age 18 years or older

    - Reside in Canada

    - Have access to a computer/touchscreen device

    - Can provide informed consent

    - Do not have a diagnosis of dementia

    - Additionally, we are enrolling participants who have previously or currently care for persons with dementia for caregiver-specific assessments

    - Ability to speak English

    Recruitment End Date

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