Eligibility Criteria

• Are between 55-85 years of age

• Have a parent or sibling with Alzheimer’s disease or with dementia that may be due to Alzheimer’s disease (even if not diagnosed as such)

• Feel your memory is getting worse

• Get normal scores on tests of thinking and memory (will be done as part of the study)

• Are able to undergo brain MRI scans

• Have a study partner (friend or family member) willing to answer questionnaires about you

• Show increased brain signaling during the screening fMRI scan (Note: We anticipate that most people who sign up for the study will NOT show the increased brain activity levels required to qualify for the study treatment)

Eligibility Criteria

• Are 50 years or older
• Have been diagnosed with mild to early-moderate Alzheimer's disease (including mixed dementia)
• Are medically stable and able to take part safely
• Experience mild to moderate depressive symptoms
• Feel comfortable using basic technology, such as a tablet or headset
• Have access to Wi-Fi and a smart device (such as a phone or tablet) for online sessions and study apps
• Have someone available to be present during all study sessions

Eligibility Criteria

Male or female participants aged 55 to 90 years of age
Must have a study partner
Presence of psychotic symptoms for at least 2 months before Screening.

Eligibility Criteria

Male or female participants aged 50 years of age to 90.
Must have a study partner
Participant- and/or Informant-reported history of cognitive decline with gradual onset and progression over the last 1 year before screening

Eligibility Criteria

Male or female participants aged 55 years of age to 90.
Must have a study partner
History of agitation due to AD.

Eligibility Criteria

Male or female participants aged 40 to 80 years of age
Has mild cognitive impairment (MCI) or dementia due to AD

Eligibility Criteria

To be eligible to participate in this study you must:

• be 60 years of age or older

• be living independently in the community

• have normal or corrected-to-normal vision and hearing

• read, write, and speak English fluently

• have feelings of memory decline in the past 5 years

• be able to exercise at a moderate pace for 60 minutes 3x/week receive clearance from a medical doctor (once deemed eligible) to participate in an exercise program

You are ineligible to participate in this study if you:

• cannot partake or commit to exercise training 3x/week for 26 weeks or have regularly engaged in exercise (more than once per week) over the past 3 months

• cannot partake or commit to consuming a daily supplement for 26 weeks or consumed nutritional supplements containing creatine monohydrate over the past 3 months

• have a known allergy to creatine monohydrate or dextrose (glucose, D-glucose)

• have been diagnosed with a neurological disorder (e.g., Alzheimer’s disease, Parkinson’s disease)

• have pre-existing kidney disease, heart disease, or liver abnormalities

• have one or more uncontrolled chronic or psychiatric conditions (e.g., hypertension, diabetes, depression, anxiety)

• are taking medication that may impact kidney function (e.g., non-steroidal anti-inflammatory drugs, such as ibuprofen and naproxen)

• are ineligible or uncomfortable with blood sampling.

Eligibility Criteria

1.) Diagnosed with Dementia and/or memory loss by a clinician

2.) Exhibit adequate oral communication skills and cognitive function

3.) Walk or stand with or without personnel or assistive devices

4.) Individuals must be greater than or equal to 50 years of age

Eligibility Criteria

- are between the ages 60-90

- have up to grade 12 education

- have an individual (spouse, friend, or relative), called a “study partner,” who is willing to:

- Accompany you to the study visits

- Communicate to the study staff of changes in your health status over the period of this study