Eligibility Criteria

Male or female participants aged 55 years of age to 90.
Must have a study partner
History of agitation due to AD.

Eligibility Criteria

Male or female participants aged 50 years of age to 85.
Must have a study partner
Diagnosis of Mild Cognitive Impairment (MCI) due to AD or mild AD

Eligibility Criteria

Male or female participants aged 40 to 80 years of age
Has mild cognitive impairment (MCI) or dementia due to AD

Eligibility Criteria

To be eligible to participate in this study you must:

• be 60 years of age or older

• be living independently in the community

• have normal or corrected-to-normal vision and hearing

• read, write, and speak English fluently

• have feelings of memory decline in the past 5 years

• be able to exercise at a moderate pace for 60 minutes 3x/week receive clearance from a medical doctor (once deemed eligible) to participate in an exercise program

You are ineligible to participate in this study if you:

• cannot partake or commit to exercise training 3x/week for 26 weeks or have regularly engaged in exercise (more than once per week) over the past 3 months

• cannot partake or commit to consuming a daily supplement for 26 weeks or consumed nutritional supplements containing creatine monohydrate over the past 3 months

• have a known allergy to creatine monohydrate or dextrose (glucose, D-glucose)

• have been diagnosed with a neurological disorder (e.g., Alzheimer’s disease, Parkinson’s disease)

• have pre-existing kidney disease, heart disease, or liver abnormalities

• have one or more uncontrolled chronic or psychiatric conditions (e.g., hypertension, diabetes, depression, anxiety)

• are taking medication that may impact kidney function (e.g., non-steroidal anti-inflammatory drugs, such as ibuprofen and naproxen)

• are ineligible or uncomfortable with blood sampling.

Eligibility Criteria

You are eligible to participate if you are 60 years or older, have a confirmed diagnosis of Alzheimer’s disease, remain relatively independent in your day-to-day life, are able and willing to wear digital activity tracking technology to monitor daily activity patterns, and are able to provide informed consent and participate in study procedures. You are also eligible to participate if you are a partner/caregiver as a healthy control. 

Eligibility Criteria

1.) Diagnosed with Dementia and/or memory loss by a clinician

2.) Exhibit adequate oral communication skills and cognitive function

3.) Walk or stand with or without personnel or assistive devices

4.) Individuals must be greater than or equal to 50 years of age

Eligibility Criteria

- You are currently an unpaid caregiver for someone living with dementia in Canada

- You have been in this caregiving role for at least 1 year

- The person you care for may live with you, in their own home or in long-term care

- You must be able to complete an online questionnaire in English

- You have access to an internet connection and device

Eligibility Criteria

- are between the ages 60-90

- have up to grade 12 education

- have an individual (spouse, friend, or relative), called a “study partner,” who is willing to:

- Accompany you to the study visits

- Communicate to the study staff of changes in your health status over the period of this study

Eligibility Criteria

You are eligible to participate if you:

1) Are between 40-75 years old, inclusive.

2) Meet diagnosis of a major depressive episode determined through a structured clinical interview conducted by the study clinical psychologist

3) Are currently experiencing a major depressive episode of at least 3 months in length.

4) Have the ability to understand and comply with the requirements of the study, as judged by the investigator(s).